Uji Aktivitas Penghambatan Enzim Tirosinase Serta Uji Iritasi Sediaan Masker Peel-Off Ekstrak Etanol Daun Sukun (Artocarpus Altilis F)

Authors

  • Devi Ratnasari Universitas Singaperbangsa Karawang
  • Fiona Rosa Sofyanita Sekolah Tinggi Teknologi Industri dan Farmasi Bogor
  • Padmono Citroreksoko Sekolah Tinggi Teknologi Industri dan Farmasi Bogor

DOI:

https://doi.org/10.35706/pc.v1i1.4419

Abstract

Abstrak : Daun sukun (Artocarpus altilis F) diketahui memiliki senyawa metabolit sekunder salah satunya adalah flavonoid. Pada penelitian ini ekstrak etanol 96% daun sukun (Artocarpus altilis F) dan sediaan masker peel-off ekstrak etanol 96% Artocarpus alitilis diuji aktivitas penghambatan enzim tirosinase menggunakan substrat L-tirosin dan L-dopa. Hasil uji aktivitas penghambatan enzim tirosinase menunjukkan bahwa ekstrak dan sediaan tidak memiliki kemampuan penghambatan terhadap melanin yang dilihat dari nilai . Ekstrak etanol 96% daun sukun memiliki nilai  dengan substrat L-tirosin sebesar 4889,467 ppm dan substrat L-Dopa sebesar 6916,626 ppm. Sediaan masker peel-off memiliki nilai  dengan substrat L-tirosin sebesar 12680,48 dan untuk substrat L-Dopa sebesar 33402,96 ppm. Dilakukan uji iritasi primer pada sediaan masker peel-off ekstrak etanol daun sukun. Hasil uji iritasi primer tidak menunjukkan adanya iritasi pada kulit seperti edema, maupun eritema.

Kata Kunci: Ekstrak etanol 96%, Daun sukun, Masker peel-off, Enzim tirosinase.

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Published

2020-11-10

How to Cite

1.
Ratnasari D, Sofyanita FR, Citroreksoko P. Uji Aktivitas Penghambatan Enzim Tirosinase Serta Uji Iritasi Sediaan Masker Peel-Off Ekstrak Etanol Daun Sukun (Artocarpus Altilis F). PharmaCine [Internet]. 2020 Nov. 10 [cited 2025 Dec. 5];1(1):16-24. Available from: https://journal.unsika.ac.id/index.php/pharmac/article/view/4419

Issue

Vol. 1 No. 1 (2020): PharmaCine: Journal of Pharmacy, Medical and Health Science

Section

Original Article

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